With the publication of these two volumes the ground has now been prepared for a long awaited event, the critical edition of the works of Henry of Ghent. Henry was one of the outstanding philosophizing-theologians at the University of Paris in the second half of the thirteenth century and, during the period between the death of Thomas Aquinas in 1274 and the ascendancy of John Duns Scotus near the beginning of the fourteenth century, no other Master surpassed him in terms (...) of influence or importance. During his tenure there as Master in the theology faculty, Henry conducted fifteen Quodlibetal disputes. His written versions of these, along with his Summa of ordinary Disputed Questions, constitute his most important surviving works. And of these, his Quodlibets rank first. Henry's philosophical and theological views were highly original and drew considerable reaction from other leading Masters of the time, especially from Giles of Rome, Godfrey of Fontaines, and somewhat later, from Duns Scotus. While his personal thought cannot be reduced to that of any earlier thinker or tradition, his views were heavily influenced by Augustine, by Avicenna, and by various other Neoplatonic currents. At the same time, while he was quite familiar with the texts and thought of Aristotle, he reacted strongly against the more radical form of Aristotelianism developed by Siger of Brabant, Boethius of Dacia, and other Masters in the Arts Faculty at Paris in the 1260s and 1270s. Aquinas's incorporation of many Aristotelian positions into his own thought was also suspect in Henry's eyes. Given this background, Henry himself may be regarded as an outstanding representative of the Neo-Augustinian philosophical current which surfaced at Paris around 1270, which triumphed with the condemnation of 219 propositions by Stephen Tempier, Bishop of Paris, in 1277, and which would continue to be a dominant philosophical force until the end of the century. The need for a critical edition of his Quodlibets and his Summa has long been recognized, since the only printed versions date from the sixteenth and seventeenth centuries. In these first two volumes of Henry's Opera omnia Macken has prepared the way for the critical edition of Henry's works and especially of his Quodlibets. Here one finds a valuable catalog, based on first-hand inspection, of the widely scattered manuscripts of Henry's works. The catalog also contains expert codicological descriptions of the contents of these manuscripts, including works whose authenticity remains doubtful. Manuscripts are also considered which contain works that treat ex professo of Henry's doctrine. This is followed by an appendix which surveys ancient references to other manuscripts allegedly containing Henry's works, which manuscripts have not yet been found. Then there is a Répertoire, not of manuscripts but of Henry's works themselves, including certainly authentic works, works of doubtful authenticity, and finally, in another short appendix, works which have been falsely ascribed to him. A third part of this survey of Henry's works is devoted to manuscripts of other writers who discuss Henry's doctrine ex professo. The two volumes conclude with all the necessary indices. One must congratulate Macken for the care, the industry, and the meticulous scholarship with which he has prepared these two volumes. Not only are they of great value to anyone interested in the manuscript tradition of Henry's works and doctrine; they also include helpful descriptions of the writings of many other medieval authors which are contained in many of these same manuscripts. They will undoubtedly be carefully combed for decades to come by other scholars interested in these same authors and manuscripts. These volumes will be indispensable for libraries of institutions making any serious claim to expertise in the history of medieval philosophical and theological thought. One can only wish Macken and his international team of collaborators every success in their next immediate task, the actual edition of Henry's most important works, his fifteen Quodlibetal Questions.--J.F.W. (shrink)

Our ability to select relevant information from the environment is limited by the resolution of attention – i.e., the minimum size of the region that can be selected. Neural mechanisms that underlie this limit and its development are not yet understood. Functional MRI was performed during an object tracking task in 7- and 11-year-old children, and in young adults. Object tracking activated canonical fronto-parietal attention systems and motion-sensitive area MT in children as young as 7 years. Object tracking performance improved (...) with age, together with stronger recruitment of parietal attention areas and a shift from low-level to higher-level visual areas. Increasing the required resolution of spatial attention – which was implemented by varying the distance between target and distractors in the object tracking task – led to activation increases in fronto-insular cortex, medial frontal cortex including anterior cingulate cortex (ACC) and supplementary motor area, superior colliculi, and thalamus. This core circuitry for attentional precision was recruited by all age groups, but ACC showed an age-related activation reduction. Our results suggest that age-related improvements in selective visual attention and in the resolution of attention are characterized by an increased use of more functionally specialized brain regions during the course of development. (shrink)

Background While integrating genomic sequencing into clinical care carries clear medical benefits, it also raises difficult ethical questions. Compared to traditional sequencing technologies, genomic sequencing and analysis is more likely to identify unsolicited findings (UF) and variants that cannot be classified as benign or disease-causing (variants of uncertain significance; VUS). UF and VUS pose new challenges for genetic health professionals (GHPs) who are obtaining informed consent for genomic sequencing from patients.Methods We conducted semi-structured interviews with 31 GHPs across Europe, Australia (...) and Canada to identify some of these challenges.Results Our results show that GHPs find it difficult to prepare patients to receive results because a vast amount of information is required to fully inform patients about VUS and UF. GHPs also struggle to engage patients – many of whom may be focused on ending their ‘diagnostic odyssey’ – in the informed consent process in a meaningful way. Thus, some questioned how ‘informed’ patients actually are when they agree to undergo clinical genomic sequencing.Conclusions These findings suggest a tension remains between sufficient information provision at the risk of overwhelming the patient and imparting less information at the risk of uninformed decision-making. We suggest that a shift away from ‘fully informed consent’ toward an approach aimed at realizing, as far as possible, the underlying goals that informed consent is meant to promote. (shrink)

Background While integrating genomic sequencing into clinical care carries clear medical benefits, it also raises difficult ethical questions. Compared to traditional sequencing technologies, genomic sequencing and analysis is more likely to identify unsolicited findings (UF) and variants that cannot be classified as benign or disease-causing (variants of uncertain significance; VUS). UF and VUS pose new challenges for genetic health professionals (GHPs) who are obtaining informed consent for genomic sequencing from patients.Methods We conducted semi-structured interviews with 31 GHPs across Europe, Australia (...) and Canada to identify some of these challenges.Results Our results show that GHPs find it difficult to prepare patients to receive results because a vast amount of information is required to fully inform patients about VUS and UF. GHPs also struggle to engage patients – many of whom may be focused on ending their ‘diagnostic odyssey’ – in the informed consent process in a meaningful way. Thus, some questioned how ‘informed’ patients actually are when they agree to undergo clinical genomic sequencing.Conclusions These findings suggest a tension remains between sufficient information provision at the risk of overwhelming the patient and imparting less information at the risk of uninformed decision-making. We suggest that a shift away from ‘fully informed consent’ toward an approach aimed at realizing, as far as possible, the underlying goals that informed consent is meant to promote. (shrink)

When Gamurrini first published the Peregrinatio ad loca sancta, the narrative by an abbess of a pilgrimage undertaken to the Holy Land in the last quarter of the fourth century, he identified the authoress with Silvia, the sister of Arcadius' minister Rufinus. Heraeus, however, in his edition lends the weight of his authority to the view that the work was written by a certain Aetheria, and in his preface gives solid reasons for his preference. He also states that a thirteenth-century (...) catalogue of the Limoges Cathedral Library mentions the book under the title Itinevarium Egenae abbatissae, but he regards the form Egeria as a mere corruption. (shrink)